Final answer:
Glucose is not a major electrolyte that needs replacement in the body.
Step-by-step explanation:
The major electrolytes that need replacement in the body are sodium, potassium, calcium, and glucose. Glucose, however, is not considered a major electrolyte that needs replacement, as it is a form of sugar and does not function as an electrolyte like sodium, potassium, and calcium do. Electrolytes such as sodium, potassium, and calcium are essential for nerve conduction, muscle contractions, and fluid balance in the body.