Final answer:
The statement that significant life changes can lead to a greater chance of illness is true according to Holmes and Rahe's Social Readjustment Rating Scale research, indicating that stress from these events can lead to physical illnesses.
Step-by-step explanation:
Thomas Holmes and Richard Rahe did indeed propose that the more significant the changes in someone's life, the greater the chance of the onset of illness. According to their research in the 1960s, they developed the Social Readjustment Rating Scale (SRRS), which includes a list of 43 life events that require various degrees of personal readjustment. These life events induce stress that can accumulate over time, potentially leading to physical illnesses. For example, even positive life events like marriage or retirement can be sources of stress and thus have the potential to affect health. Therefore, the statement that the more significant the changes in someone's life, the greater the chance of the onset of illness is True.