Final answer:
The most likely reason for Anheuser-Busch losing its independence after focusing primarily on the domestic U.S. market is opposition to globalization.
Step-by-step explanation:
The most likely reason for Anheuser-Busch losing its independence after years of focusing primarily on the domestic U.S. market is opposition to globalization. Globalization has changed the market boundaries, and many industries now face competition from the global market. In the case of Anheuser-Busch, the emergence of beer brewers from emerging markets and the increased availability of foreign beer brands in the U.S. may have posed a challenge to its dominance in the domestic market.