Final answer:
True, increasing enzyme concentration can increase the rate of a reaction at saturation because all active sites of the enzyme are occupied, and more enzymes provide additional active sites for substrate binding.
Step-by-step explanation:
The statement is true; once an enzyme-mediated reaction reaches saturation, the best way to increase the rate of a reaction is to increase the amount of enzyme available. This is because, at saturation, all the enzyme's active sites are occupied by the substrate, meaning that adding more substrate would not increase the rate of the reaction. Therefore, to facilitate more reactions, additional enzymes must be introduced so that more active sites are available for the substrate to bind to, ultimately increasing the reaction rate.