Final answer:
The dependent variable in a between-subjects design is the one that should be affected by the manipulation of the independent variable, as opposed to being manipulated itself. A potential issue could be inaccurate measurement, but that is not an inherent problem of the design.
Step-by-step explanation:
The issue with the dependent variable in a between-subjects design is not that it is not manipulated by the researcher. In fact, the dependent variable is the one that is expected to be affected by the independent variable. The independent variable, on the other hand, is the one that is controlled and manipulated by the researcher to observe its effect on the dependent variable. In such a design, a potential issue might be that the dependent variable is not measured accurately, but this is not inherent to the design itself. Furthermore, it is essential that the dependent variable is relevant to the research question being asked for the study to have valid conclusions.