Question

The endosteum is a region of the bone marrow where __________

a) immature B cells are exported to the circulation
b) small pre-b cells initiate the rearrangement of light-chain genes
c) a high proportion of hematopoietic stem cells reside
d) late pro-b cells accumulate while completeing rearrangement of heavy-chain genes

Answer 1

The endosteum is a region of the bone marrow where a high proportion of hematopoietic stem cells reside, which are essential for the production of various types of blood cells including B cells that mature in the bone marrow.

Step-by-step explanation:

The endosteum is a region of the bone marrow where a high proportion of hematopoietic stem cells reside. The red bone marrow is where hematopoiesis, the process of blood cell production, including B cells, occurs.

Throughout this process, hematopoietic stem cells differentiate into various cell types, including the myeloid lineage that gives rise to erythrocytes and leukocytes and the lymphoid lineage that further develops into B cells within the bone marrow or T cells in the thymus gland. While B cells mature almost entirely in the red bone marrow, T cells, or thymocytes, leave the marrow and continue their maturation in the thymus.