Final answer:
True. The antigen-binding properties of immunoglobulins vary due to variation in the amino acid sequence of the V domain loops.
Step-by-step explanation:
True. The antigen-binding properties of immunoglobulins are indeed different as a result of variation in the amino acid sequence of the loops of the V domains. The variable region domain of immunoglobulins exhibits high diversity in amino acid sequence, especially in the hypervariable regions known as complementarity determining regions (CDRs). These CDRs form the antigen-binding surface, where the unique patterns of amino acids can bind to target antigens with complementary charges and noncovalent bonds.