Question

Negative selection of developing B cells ensures that

a. there is not an overabundance of circulating B cells that would compete with other important cell types in the circulation
b. only antigen-activated B cells leave the bone marrow
c. clonal expansion of B cells does not occur in the absence of infection
d. B-cell receptors that bind to normal constituents of the body do not emerge
e. B cells do not leave secondary lymphoid tissues.

Answer 1

Negative selection of developing B cells ensures that B-cell receptors that bind to normal constituents of the body do not emerge.

Step-by-step explanation:

Negative selection of developing B cells ensures that B-cell receptors that bind to normal constituents of the body do not emerge. This mechanism eliminates self-reacting B cells and minimizes the risk of autoimmunity. It involves processes such as apoptosis, editing or modification of receptors, or induction of anergy in the B cell. This ensures that only B cells with normal functional receptors leave the bone marrow and that an overabundance of circulating B cells, which could compete with other important cell types in the circulation, is not present.