Question

Which of the following is characteristic of a large pre-B cell?

a. VDJ is successfully rearranged and μ heavy chain is made.
b. V-J is rearranging at the light-chain locus.
c. μ heavy chain and λ or κ light chain is made.
d. V is rearranging to DJ at the heavy-chain locus.
e. D-J is rearranging at the heavy-chain locus.

Answer 1

A characteristic of a large pre-B cell is that VDJ is successfully rearranged and μ heavy chain is made, indicating that the heavy chain locus has undergone recombination necessary for further B cell development.

Step-by-step explanation:

A characteristic of a large pre-B cell is a. VDJ is successfully rearranged and μ heavy chain is made. During the development of B cells, they undergo genetic rearrangement to provide the diversity necessary for antigen recognition. In large pre-B cells, the heavy chain locus has undergone successful VDJ recombination, resulting in the production of the μ heavy chain. At this stage, the light chain has not yet rearranged, which happens later in development. This process of rearrangement and the eventual production of μ heavy chains are essential steps in the maturation of B cells, leading to the functional diversity of antibodies they can produce.