Question

Which of the following indicate severely impaired oxygenation requiring high FIO₂ and positive end-expiratory pressure?

1. PAO₂-PaO₂ greater than 350 mm Hg on 100% O₂
2. VC less than 10 mL/kg
3. PaO₂/FIO₂ less than 200
a. 1 and 2
b. 1 and 3
c. 2 and 3
d. 1, 2, and 3

Answer 1

The indicators that suggest severely impaired oxygenation requiring high FIO₂ and positive end-expiratory pressure are PAO₂-PaO₂ greater than 350 mm Hg on 100% O₂, VC less than 10 mL/kg, and PaO₂/FIO₂ less than 200.

Step-by-step explanation:

To indicate severely impaired oxygenation requiring high FIO₂ and positive end-expiratory pressure, we need to look at the indicators given.

The PAO₂-PaO₂ (the difference between the partial pressure of oxygen in the alveoli and the arterial blood) is greater than 350 mm Hg on 100% oxygen, which indicates severe oxygenation impairment.

A VC (vital capacity) of less than 10 mL/kg indicates a severe reduction in lung capacity.

A PaO₂/FIO₂ (ratio of arterial oxygen partial pressure to the fraction of inspired oxygen) of less than 200 indicates a severe impairment in oxygen exchange.

Therefore, the correct option is answer choice d. 1, 2, and 3 as they all indicate severely impaired oxygenation.