The three main differences between plant and animal cells are:
1. Plant cells have a cell wall, a structure that's located outside the plasma membrane to protect the cell. Animal cells will never show a cell wall.
2. Plant cells have chloroplasts, organelles needed for photosynthesis to take place. This is what makes a plant an autotroph. Animal cells will never show a chloroplast.
3. Plant cells do not have centrioles and centrosomes, but animal cells do. Also, plant cells always shows one or a few large vacuoles, while in animal cells vacuoles are small and in a large number.