Final answer:
To calculate the number of anagrams for four unique letters, one would use 4 factorial (4!), which equals 24 different combinations.
Step-by-step explanation:
The question asks how many different anagrams can be made from a set of letters. To determine the number of anagrams, we use factorial calculation. For a set of four unique letters, the number of anagrams is calculated as 4! (four-factorial), which equals 4 × 3 × 2 × 1.
This gives us a total of 24 different combinations. It's a useful exercise to systematically create these anagrams to better understand the permutation process and to discover the rationale behind the mathematical formula for counting combinations.