Final answer:
The Mississippi River carries a strong cultural significance for those who have lived on it due to its portrayal in songs, stories, and its role in economic activities.
Step-by-step explanation:
The Mississippi River carries a strong cultural significance for those who have lived on it. Songs and stories have portrayed the river as a symbol of regional identity and historical heritage. The river's role in economic activities such as the cotton industry in the South also contributes to its cultural significance.