Final answer:
Atropisomerism by Design refers to intentionally designing compounds that exhibit atropisomerism, a type of stereochemistry caused by hindered rotation around a single bond. Atropisomers can impact chemical reactivity, biological selectivity, structural stability, and enzymatic activity.
Step-by-step explanation:
Atropisomerism by Design refers to the intentional design of compounds that exhibit atropisomerism, a type of stereochemistry caused by hindered rotation around a single bond. Atropisomerism can have various effects on chemical reactivity, biological selectivity, structural stability, and enzymatic activity.
This type of stereochemistry can expand chemical reactivity by creating different reaction pathways depending on the specific atropisomer. For example, certain atropisomers may have enhanced reactivity towards certain compounds or functional groups.
In terms of biological selectivity, atropisomers can interact differently with specific enzymes or receptors, leading to differences in their biological activity. This can be useful in drug design, where selective interaction with a target enzyme is desired.
Atropisomerism can also induce structural instability in certain compounds, as hindered rotation around the single bond can lead to strain or unfavorable conformations. This can have implications in terms of stability and reactivity of the compound.
Lastly, atropisomerism can suppress enzymatic activity by inhibiting or modulating the active site of an enzyme. This can be exploited in the design of enzyme inhibitors or modulators.