Final answer:
The publication of Uncle Tom's Cabin in 1852 had its greatest impact on northern public opinion regarding abolition of slavery.
Step-by-step explanation:
The publication of Uncle Tom's Cabin in 1852 had its greatest impact on northern public opinion regarding abolition of slavery. The novel, written by Harriet Beecher Stowe, depicted the harsh conditions of slavery, the struggle of enslaved people to escape, and the detrimental effects of slavery on slave owners.
Uncle Tom's Cabin sold over a million copies by 1853 and played a significant role in raising awareness and stirring public sentiment against slavery in the North.