Final answer:
The hallmark of cancer refers to the distinct characteristics that define cancerous cells. All of the options are hallmarks of cancer except apoptosis, which is programmed cell death.
Step-by-step explanation:
The hallmark of cancer refers to the distinct characteristics that define cancerous cells. All of the following are hallmarks of cancer: sustained cell production, angiogenesis (the formation of new blood vessels), and metastasis (the spread of cancerous cells to other parts of the body). However, apoptosis, which is programmed cell death, is not a hallmark of cancer. Cancer cells often evade apoptosis, allowing them to survive and proliferate uncontrollably.