Final answer:
Penicillin V, due to its short half-life, requires more frequent dosing compared to azithromycin, which has a longer half-life and can be dosed less often.
Step-by-step explanation:
Penicillin V would have to be taken more often to achieve proper dosage because it has a very short half-life. Azithromycin, on the other hand, has a half-life of over 24 hours, allowing for less frequent dosing. Half-life is a key factor that determines the dosing frequency of drugs, and drugs with shorter half-lives are typically administered more frequently than those with longer half-lives to maintain effective therapeutic levels in the body.