Question

Prior to migration, neural crest cells undergo a transition, in which they:

(A) change down regulate e cadherin
(B) extend lamellipodia
(C) form the neural tube
(D) undergo cell division

Answer 1

Neural crest cells down-regulate E-cadherin during their transition prior to migration, which facilitates their release from the neuroepithelium and allows them to migrate and differentiate into various cell types.

Step-by-step explanation:

Prior to migration, neural crest cells undergo a transition characterized by several key processes. As part of this transition, these cells down-regulate E-cadherin which is pivotal for decreasing cell-to-cell adhesion, allowing the cells to release from the neuroepithelium and migrate to their final destinations where they differentiate into various cell types. These cells are integral to the formation of the peripheral nervous system and other structures such as craniofacial cartilage and bone, and melanocytes. It should be noted that the formation of the neural tube precedes the migration and occurs due to the convergence of the neural folds from which neural crest cells emerge.