Question

Following changes in confirmation due to steroid hormones, what type of signal would you expect to be exposed on the cytosolic receptor based on nuclear transport?

A) Nuclear localization signal (NLS)
B) Nuclear export signal (NES)
C) Mitochondrial targeting sequence (MTS)
D) Endoplasmic reticulum retention signal (ERS)

Answer 1

For a cytosolic receptor affected by steroid hormones, a Nuclear localization signal (NLS) would be exposed to facilitate its transport into the nucleus, where it can influence gene transcription.

Step-by-step explanation:

The signal you would expect to be exposed on the cytosolic receptor following changes in confirmation due to steroid hormones, based on nuclear transport, is a Nuclear localization signal (NLS). Steroid hormones permeate the plasma membrane and bind to cytosolic receptors.

This triggers a conformational change in the receptor, causing it to release associated proteins such as heat shock proteins (HSP) and reveal a NLS that is rich in positively charged amino acids. The exposed NLS enables the receptor-hormone complex to be recognized by nuclear transport receptors, facilitating its translocation into the nucleus..

There, the complex can bind to hormone response elements (HRE) on the DNA, initiating transcription and ultimately affecting protein synthesis and cell function.