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Sickle-cell disease is described as a systemic disease and has an impact on the entire body. Below are descriptions of common systemic manifestations due to the sickle-shaped red blood cells blocking capillaries of the circulatory system. Please correctly match the description to the area of the body affected.

a. Cardiovascular system

b. Respiratory system

c. Central nervous system

d. Gastrointestinal system

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Final answer:

Sickle-cell disease has systemic manifestations that affect different areas of the body, including the cardiovascular, respiratory, central nervous, and gastrointestinal systems.

Step-by-step explanation:

Sickle-cell disease can have systemic manifestations that affect different areas of the body. The crescent-shaped red blood cells can block capillaries and interrupt blood flow, leading to various complications. Here are the common systemic manifestations and the areas of the body they affect:



  1. Cardiovascular system: The blockage of blood vessels can cause decreased blood flow and oxygen supply, leading to cardiovascular issues.
  2. Respiratory system: The obstructed blood flow can affect the lungs, causing breathing difficulties and respiratory problems.
  3. Central nervous system: The blockage of blood vessels in the brain can lead to strokes and other neurological complications.
  4. Gastrointestinal system: The interruption of blood flow in the digestive system can cause abdominal pain and other gastrointestinal issues.

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