Final answer:
The referenced article mainly focuses on Fc-dependent antibody effector functions in the context of SARS-CoV-2, which include complex immune responses beyond just neutralizing the virus.
Step-by-step explanation:
The main focus of the article by Zhang A, Stacey HD, D'Agostino MR, Tugg Y, Marzok A, Miller MS published in Nat Rev Immunol is on Fc-dependent antibody effector functions in SARS-CoV-2 infection. These effector functions go beyond simple neutralization of the virus, involving complex immune mechanisms such as antibody-dependent cell-mediated cytotoxicity (ADCC). ADCC operates when the Fab region of an IgG antibody attaches to a pathogen, and Fc receptors on effector cells bind the antibody's Fc region, leading to the pathogen's destruction by cells like NK cells, which release cytotoxins. The antibody functions include tagging pathogens for destruction and activating the complement cascade, illustrating the vital role that antibodies play in connecting adaptive and innate immunity.