Final answer:
The most accurate description of the encounter between Spanish and Native Americans is that the indigenous people suffered the loss of their land, enslavement, and death due to wars and diseases introduced by the Spanish.
Step-by-step explanation:
The statement that best describes the encounter between Spanish and Native Americans is C. Native Americans lost their land, were forced to work as slaves, and were killed by war or disease. The Spanish arrival in the Americas brought devastating effects on Native American societies, including the imposition of the Encomienda System, which forced indigenous peoples into servitude.
Many Native Americans resisted the Spaniards' efforts to control their labor and to change their ancient belief systems. Moreover, the introduction of European diseases like smallpox, to which Native Americans had no immunity, resulted in the death of a large portion of the indigenous population.