Question

In order to accurately deliver 1:10 dilution of 2.27% enrofloxacin to a 40 g (1.41 oz) parakeet that needs to be treated with 5 mg/kg IM, which of the following volume values is required?

A. 0.009 mL
B. 0.09 mL
C. 0.9 mL
D. 9.0 mL

Answer 1

To ascertain the required volume for the 1:10 dilution, the dose for the parakeet is first calculated, then the initial concentration is converted to mg/mL, diluted, and used to determine the volume, which is 0.09 mL.

Step-by-step explanation:

To determine the required volume to accurately deliver a 1:10 dilution of 2.27% enrofloxacin for a 40 g parakeet that needs to be treated with 5 mg/kg IM, first calculate the necessary dose in milligrams:

• Parakeet weight = 40 g
• Dose = 5 mg/kg = (5 mg/kg) × (40 g) × (1 kg/1000 g) = 0.2 mg

Next, convert the 2.27% enrofloxacin solution to mg/mL:

• 2.27% w/v = 2.27 g/100 mL = 22.7 mg/mL

To achieve a 1:10 dilution, the concentration is divided by 10:

• (22.7 mg/mL) / 10 = 2.27 mg/mL

Finally, calculate the volume needed using the diluted concentration:

• Volume (V) = Dose / Diluted concentration = 0.2 mg / 2.27 mg/mL = 0.0881 mL

Thus, the required volume is option B 0.09 mL.