Final answer:
Plaque formation in coronary artery disease primarily results from the accumulation of LDL particles, which are also known as 'bad' cholesterol. These particles initiate plaque build-up by depositing cholesterol in artery walls and instigating an inflammatory response.
Step-by-step explanation:
The plaque formation found in coronary artery disease is primarily due to the accumulation of Low-Density Lipoproteins (LDL) particles. LDL is often referred to as 'bad' cholesterol because it contributes to the formation of plaques by depositing cholesterol within the artery walls. This process begins when LDL particles accumulate inside the endothelial cells and trigger inflammation. White blood cells are then attracted to the site, forming a base for the plaques. As the process continues, these plaques grow and can become calcified or mixed with connective tissue, leading to a narrowed or blocked coronary artery, which is a significant concern in coronary artery disease.