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Serum Albumin & Prealbumin: which is used for monitoring, which for baseline assessment?

What is the half-life of each?
Is prealbumin a precursor for albumin?

User Danielo
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Final answer:

Serum Albumin is used for baseline health assessment with a half-life of around 20 days. Prealbumin, with a half-life of about 2 days, is used for rapid monitoring but is not a precursor to Albumin. Both proteins are synthesized in the liver and involved in the transport of various substances.

Step-by-step explanation:

Serum Albumin and Prealbumin play significant roles in the body and are used in the clinical monitoring of nutritional status and other conditions. Serum Albumin, which constitutes about half of the blood serum protein, is utilized to provide a baseline assessment of a patient's health, especially in chronic conditions. It is synthesized in the liver and plays a critical role in transporting hormones and fatty acids, buffering pH, and maintaining osmotic pressure. The half-life of Serum Albumin is approximately 20 days, which reflects long-term nutritional status.

Prealbumin, on the other hand, is often used for monitoring and has a much shorter half-life of about 2 days, which allows it to reflect more rapid changes in protein status. Contrary to what its name suggests, Prealbumin is not a precursor to Albumin. It is also synthesized in the liver and serves as a carrier for thyroxine and retinol-binding protein.

User Tom Bull
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