Question

During a DUR, a RPh MUST verify the feasibility to dispense a drug based upon:

Answer 1

A Registered Pharmacist (RPh) must verify the feasibility to dispense a drug during a Drug Utilization Review (DUR) based on factors such as extraction conditions, validation of the assay, food effect on pharmacokinetics, and drug-drug interactions.

Step-by-step explanation:

During a Drug Utilization Review (DUR), a Registered Pharmacist (RPh) must verify the feasibility to dispense a drug based upon several factors:

1. Finalization of extraction, chromatographic, and detection conditions based on anticipated concentrations following the lowest dose in humans.
2. Full validation of the assay, including selectivity, linearity, LLOQ, LOD, accuracy, precision, recovery, and stability experiments.
3. Investigation of the food effect on pharmacokinetics and selection of the best formulation for drug exposure.
4. Verification of drug-drug interactions with commonly co-prescribed agents or with narrow safety window.

These considerations are crucial to ensure the safety and efficacy of the drug being dispensed.