Final answer:
Insulin resistance can cause skin changes such as acanthosis nigricans and acrochordons (skin tags), which are related to abnormalities in insulin receptor function leading to type 2 diabetes. Gastrointestinal malignancy does not have specific skin presentations closely related to insulin resistance or diabetes.
Step-by-step explanation:
Insulin resistance is a condition characterized by the inability of cells to effectively use insulin. This impairment can be manifest through various skin presentations, including acanthosis nigricans, which appears as dark, velvety discoloration in body folds and creases, and is commonly associated with insulin resistance. Acrochordons, also known as skin tags, are another skin condition linked to insulin resistance.
Pathology of insulin receptors is a crucial aspect of understanding insulin resistance. The activation of insulin receptors is essential for glucose uptake, and their malfunction can lead to type 2 diabetes as a result of hyperglycemia. Risk factors for type 2 diabetes include obesity and metabolic syndrome, which can all contribute to increased resistance to insulin.
On the other hand, skin presentations related to gastrointestinal malignancy are not as closely linked to disorders of insulin resistance; however, systemic diseases including malignancies may sometimes be reflected in skin symptoms, although not specific ones such as acanthosis nigricans or acrochordons which are more specific to insulin resistance.