Final answer:
To consider a hemoglobin level as trans, it should be associated with the presence of abnormal hemoglobin variants such as HbS in conditions like sickle cell anemia.
Step-by-step explanation:
In order for a Hemoglobin (Hb) level to be considered as trans, it would typically refer to a condition where there is an abnormal variant of Hemoglobin present. One example is sickle cell anemia, which is caused by a single amino acid substitution in the beta chain of hemoglobin.
Specifically, sickle cell hemoglobin (HbS) arises due to a defect in the ß chain where a glutamic acid at the 6th position is replaced by valine. This replacement leads to the formation of sticky patches on HbS, resulting in the characteristic sickle shape of red blood cells.
So, to consider a Hb level as trans, it should be associated with the presence of abnormal hemoglobin variants such as HbS.