Final answer:
The antidote for opioids is Naloxone. It is an opioid antagonist that quickly reverses the effects of an overdose, significantly differing from other substances like Methadone, Buprenorphine, and Naltrexone that serve different roles in opioid addiction management.
Step-by-step explanation:
The antidote for opioids is Naloxone (option 1). Naloxone is a medication used to counter the effects of opioid overdose, such as life-threatening depression of the central nervous system and respiratory system, allowing an overdose victim to breathe normally. Unlike other medications that can also treat opioid dependency or withdrawal, such as Methadone and Buprenorphine, Naloxone is used during an overdose situation to quickly reverse the effects of the opioid. Naltrexone, while also an opioid antagonist, is not used for acute overdose reversal but rather for long-term addiction management due to its oral administration and longer duration of action.