Final answer:
The priority intervention for a neonate at risk of drug withdrawal is to place the Isolette in a quiet area to create a calm environment, which helps mitigate withdrawal distress.Hence, the correct answer is option 2.
Step-by-step explanation:
When caring for a neonate whose mother was abusing drugs, and anticipating the possibility of drug withdrawal, the priority intervention would be to place the Isolette in a quiet area of the nursery (Option 2). This is because a neonate undergoing withdrawal may experience heightened sensitivity to sensory stimuli and may benefit from a subdued environment to promote homeostasis and well-being. Moreover, while loose clothing, medication management, and proximity to healthcare workers are important considerations, establishing a calm environment is critical for helping to mitigate the distress associated with withdrawal symptoms.