Final answer:
The ratio of men affected with Klinefelter Syndrome is approximately 1:1000. It is characterized by an extra X chromosome in males, leading to various physiological and reproductive features.
Step-by-step explanation:
The ratio of men affected with Klinefelter Syndrome is approximately 1:1000. Klinefelter Syndrome is an X-linked condition where the affected males have an extra X chromosome, leading to a genotype of XXY instead of the typical XY found in males. This syndrome can result in features such as small testes, enlarged breasts, reduced body hair, sterility, and reduced testosterone production. More complex forms of Klinefelter Syndrome can involve additional X chromosomes, and in each case, all but one of the X chromosomes undergo inactivation, which can be observed as several Barr bodies in the cell nucleus.