Final answer:
The most notable problem with adult males who have Klinefelter Syndrome is infertility, due to sterility and reduced testosterone production. Other severe side effects can include impaired heart function and prostate enlargement, but unaligned spine, premature baldness, and high risk of blindness are not typically associated with this condition.
Step-by-step explanation:
The student has asked about the problems that arise with adult males who have Klinefelter Syndrome. Among the options provided, infertility problems are a well-documented issue with Klinefelter Syndrome (47 XXY). This condition leads to sterility and reduced testosterone production due to the presence of an extra X chromosome. The physical characteristics often include small testes, enlarged breasts, and reduced body hair.
Klinefelter Syndrome can also have other severe side effects such as impaired heart function and prostate enlargement. Although unaligned spine, premature baldness, and high risk of blindness are not commonly associated with Klinefelter Syndrome, the extra X chromosome undergoes inactivation which can cause Barr bodies in each cell nucleus, indicating the effect of this condition at the genetic level.