Final answer:
A severe symptom of Angelman syndrome that occurs within the first year of birth is seizures. This neurodevelopmental disorder is characterized by developmental delays and epilepsy, among other neurological and behavioral issues.
Step-by-step explanation:
Along with developmental delays, a severe symptom that occurs within one year of birth in patients with Angelman syndrome is seizures. Angelman syndrome is a neurodevelopmental disorder characterized by developmental delays, lack of speech, epilepsy, and movement or balance issues. These symptoms, which arise due to genetic abnormalities, particularly affect the nervous system, leading to neurological and behavioral challenges.
For instance, the seizures associated with Angelman syndrome are often resistant to treatment and can be a significant concern for managing the condition. Developmental delays, in terms of both physical and intellectual growth, are prominent, and children with Angelman syndrome typically exhibit a happy demeanor, with frequent laughing, smiling, and excitability.
Early diagnosis and intervention can help manage these symptoms, with a focus on supportive therapies for developmental, communication, and behavioral challenges. Additionally, genetic testing can provide a conclusive diagnosis, identifying the typical deletion or mutation on the maternal chromosome 15 associated with the syndrome.