Final answer:
The most likely diagnosis for a patient with pseudophakia and retinitis pigmentosa, who presents with drusen but without leakage or edema, is age-related macular degeneration (AMD).
Step-by-step explanation:
A patient with pseudophakia in both eyes and diagnosed with retinitis pigmentosa, showing the presence of drusen but no leakage or macular edema, is most likely suffering from age-related macular degeneration (AMD). AMD is a condition where cells in the macula of the eye, including the retinal pigment epithelium, begin to die off, leading to vision loss with a dark spot in the central vision which can expand over time. This diagnosis aligns with the observed signs in the retina and the lack of symptoms typically associated with the other conditions listed, such as diabetic retinopathy or macular edema.