Final answer:
Bilirubin is the analyte in neonates that must be protected from light before testing to prevent changes in its levels due to light exposure.
Step-by-step explanation:
The analyte collected in neonates that should be protected from light prior to testing is bilirubin. Bilirubin, a product of erythrocyte breakdown, is neurotoxic and can cause brain damage in high concentrations, known as hyperbilirubinemia. This condition necessitates medical attention in newborns and is typically treated using phototherapy to help break down bilirubin more quickly. Due to its sensitivity to light, bilirubin levels can alter if exposed, thus samples for testing must be protected from light to maintain accuracy.