Question

Calculate the percentage of the stated content of hyoscine hydrobromide in travel sickness tablets from the following data. The assay is carried out in a manner similar to the eyedrop assay described above. The amount of atropine added as an internal standard does not enter into the calculation if we assume that the same amount is added to Solutions 1 and 3:

Weight of 20 tablets = 2.1881 g
Weight of tablet powder taken = 0.9563 g
Stated content per tablet = 0.6 mg
Concentration of hyoscine hydrobromide standard solution = 0.0341% w/v
Volume of hyoscine hydrobromide solution added to Solution 1 = 15 ml
Area of hyoscine peak in Solution 1 = 147 881
Area of atropine peak in Solution 1 = 159 983
Area of hyoscine peak in Solution 3 = 167 799
Area of atropine peak in Solution 3 = 173 378.

Answer 1

To calculate the percentage of hyoscine hydrobromide in the travel sickness tablets, use the given data to calculate the percentage using the formula. Percentage = (147,881 / 159,983) × (173,378 / 167,799) × 100 = 89.4%

Step-by-step explanation:

To calculate the percentage of hyoscine hydrobromide in the travel sickness tablets, we need to use the formula:

Percentage = (Area of hyoscine peak in Solution 1 / Area of atropine peak in Solution 1) × (Area of atropine peak in Solution 3 / Area of hyoscine peak in Solution 3) × 100

Using the given data:

• Weight of 20 tablets = 2.1881 g
• Weight of tablet powder taken = 0.9563 g
• Stated content per tablet = 0.6 mg
• Concentration of hyoscine hydrobromide standard solution = 0.0341% w/v
• Volume of hyoscine hydrobromide solution added to Solution 1 = 15 ml
• Area of hyoscine peak in Solution 1 = 147,881
• Area of atropine peak in Solution 1 = 159,983
• Area of hyoscine peak in Solution 3 = 167,799
• Area of atropine peak in Solution 3 = 173,378

Plugging in these values into the formula, we get:

Percentage = (147,881 / 159,983) × (173,378 / 167,799) × 100 = 89.4%