Final answer:
In the liver, the kinase domain is dephosphorylated to become active and phosphorylated to become inactive. Option 1 is correct.
Step-by-step explanation:
The statement is accurate. In the liver, the regulation of kinase activity involves a dynamic interplay of phosphorylation and dephosphorylation events.
When the kinase domain undergoes dephosphorylation, removing phosphate groups, it becomes active and capable of catalyzing cellular processes. Conversely, phosphorylation, the addition of phosphate groups, renders the kinase domain inactive. This finely tuned mechanism of reversible phosphorylation controls the functional state of kinases, allowing the cell to precisely modulate various biochemical pathways.
Understanding this regulatory process is crucial for comprehending cellular signaling cascades and the intricate balance that governs cellular responses in physiological and pathological conditions.
Therefore, option 1 is correct.