Final answer:
Table 11.2 provides information about the subunit composition of DNA Polymerase III Holoenzyme from E. coli. DNA Polymerase III is an essential enzyme involved in DNA replication in bacteria. The holoenzyme refers to the fully functional form of the enzyme, which consists of multiple subunits working together.
Step-by-step explanation:
The specific subunit composition described in Table 11.2 may vary, but it typically includes the following components:
- 1. Core Enzyme: The core enzyme is the catalytic center of DNA Polymerase III. It is composed of three subunits: α, ε, and θ. The α subunit has the polymerase activity, responsible for adding nucleotides to the growing DNA chain during replication. The ε subunit is involved in proofreading and editing errors in the DNA sequence. The θ subunit stabilizes the interaction between the α and ε subunits.
- 2. Clamp Loader Complex: The clamp loader complex is responsible for loading the sliding clamp onto the DNA strand, which helps to increase the processivity of the polymerase. In E. coli, the clamp loader is composed of three subunits: γ, δ, and δ'.
- 3. Sliding Clamp: The sliding clamp is a ring-shaped protein that encircles the DNA strand and tethers the polymerase to the DNA during replication. In E. coli, the sliding clamp is known as the β subunit.
- 4. Other Subunits: The holoenzyme may contain additional subunits that are not specifically mentioned in Table 11.2. These subunits can have regulatory roles or assist in the assembly and function of the polymerase complex.
Your question is incomplete, but most probably the full question was:
Provide and explain: Table 11.2: Subunit Composition of DNA Polymerase III Holoenzyme from E. coli