Question

which two factors facilitate systemic unloading of oxygen from hemoglobin in the peripheral tissues? select two answers from the list below. multiple select question. lower po2 in tissue fluid binding of protons to hemoglobin cooler temperatures active transport of o2 out of the blood stream

Answer 1

The two factors that facilitate systemic unloading of oxygen from hemoglobin in peripheral tissues are:

Lower po₂ in tissue fluid

Binding of protons to hemoglobin

The two factors that facilitate systemic unloading of oxygen from hemoglobin in peripheral tissues are:

Lower po₂ in tissue fluid: When the partial pressure of oxygen (po₂) is lower in the tissue fluid, oxygen is more readily released from hemoglobin to meet the oxygen demands of the tissues.

Binding of protons to hemoglobin: This is known as the Bohr effect. As tissues metabolize and produce carbon dioxide, which can lead to the formation of protons (H+ ions), hemoglobin's affinity for oxygen decreases. This makes it easier for oxygen to be released in tissues with higher metabolic activity.