Question

multiple select question select all that apply inactivation of the x chromosome has been associated with which of the following epigenetic changes? multiple select question. incorporation of h2a.z into nucleosomes removal of methyl groups from many cpg islands covalent histone modifications methylation of many cpg islands incorporation of h3.3 into nucleosomes incorporation of macroh2a into nucleosomes

Answer 1

X chromosome inactivation is linked to epigenetic changes like methylation of CpG islands, histone modifications, and incorporation of macroH2A into nucleosomes, which influence nucleosome packaging and gene expression.

Step-by-step explanation:

Inactivation of the X chromosome has been associated with various epigenetic changes. One of these changes is the methylation of many CpG islands, which contributes to the silencing of genes on the X chromosome. Another alteration involves various covalent histone modifications that lead to changes in chromatin structure and gene expression. Furthermore, the incorporation of macroH2A into nucleosomes is also associated with X chromosome inactivation. These epigenetic modifications result in changes to nucleosome packaging, impacting gene expression and the overall chromatin structure.