Final answer:
The Food, Drug, and Cosmetic Act (FD&C Act) is the legislation that enforced drug manufacturers to prove safety and effectiveness of their products before marketing, as well as to provide accurate information about side effects in their advertisements.Option a) Pure Food and Drug Act is correct answer.
Step-by-step explanation:
The act that required drug manufacturers to provide proof of the effectiveness and safety of their drugs before approval, as well as more closely regulated drug advertising and ensured that accurate information about side effects was disclosed, is the Food, Drug, and Cosmetic Act (FD&C Act). The Pure Food and Drug Act, passed in 1906, laid the groundwork for this by setting federal standards for inspection and sanitation for meatpackers and requiring drug makers to list ingredients. However, it was the FD&C Act, first passed in 1938 and extensively amended since then, that established the comprehensive regulatory framework for drugs and numerous other products.