In the book "Refugee," the character Isabel is impacted by Havana in a few ways. Havana represents a place of hope and freedom for Isabel and her family. They see it as their chance to escape the dangers they faced in their home country. Havana symbolizes a new beginning and a better life for them. The city and its people provide them with support and a sense of community. Havana's impact on Isabel is that it gives her strength and resilience to face the challenges of being a refugee.