Question

this pedigree shows the segregation of a rare disease in a family. what is the most likely mode of inheritance of this disease? (assume complete penetrance.) pedigree this pedigree shows the segregation of a rare disease in a family. what is the most likely mode of inheritance of this disease? (assume complete penetrance.) pedigree autosomal recessive autosomal dominant maternal imprinting paternal imprinting x-linked recessive x-linked dominan

Answer 1

The most likely mode of inheritance of this disease is option a: maternal imprinting

What is the segregation?

Maternal imprinting is an epigenetic phenomenon where certain genes inherited from the mother are chemically modified, altering their expression. During gamete formation, specific markers, such as DNA methylation, are added to the maternal allele, influencing gene activity in the offspring.

So, This modification often results in the silencing or reduced expression of the maternal gene. Maternal imprinting plays a crucial role in normal development and health. Disruptions in this process can lead to various genetic disorders, telling the significance of epigenetic regulation in shaping gene expression patterns inherited from the maternal lineage.