Question

histone deacetylase inhibitors are a class of drugs used as mood stabilizers and anti-epileptics that are also being researched for their officacy as scaner v deacetylase inhibitors block the action of histone deacetylases, which remove acetyl groups from lysine residues in histone tails. how will blocking h affect gene expression in the cell? chromatin will become more tightly compact, and gene expression will be reduced chromatin will become more tightly compact, and gene expression will be increased fromatin will become more open, and gene expression will be reduced omatin will become more open, and gene expression will be increased anatin will become more methylated, and gene expression will be decreased

Answer 1

Blocking histone deacetylases (HDACs) will result in chromatin becoming more open, and gene expression will be increased.

Histone deacetylases remove acetyl groups from lysine residues in histone tails, which leads to a more compact and condensed chromatin structure. This compact chromatin structure is associated with reduced gene expression because it restricts the access of transcription factors and other regulatory proteins to the DNA.

By inhibiting HDACs, acetyl groups remain attached to the lysine residues in histone tails, preventing the compaction of chromatin. This leads to a more open chromatin structure, allowing for easier access of transcription factors and regulatory proteins to the DNA. As a result, gene expression is increased because the transcriptional machinery can more readily bind to the DNA and initiate transcription.