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_________ __________ is a history of disease in first- and second-degree blood-relatives that reaches back at least two generations

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Final answer:

A medical pedigree, or family health history, is an account of health information among family members across generations. It is significant in identifying individuals with greater risk of developing certain genetic diseases, assisting in the formulation of individualized prevention plans.

Step-by-step explanation:

The history of disease in first- and second-degree blood-relatives reaching back at least two generations is usually referred to as a family health history or medical pedigree. It is a key tool that health care providers use to assess your risk of disease. This type of tracking often includes health information regarding grandparents, parents, and siblings, focusing on diseases that are genetically inherited.

In a medical pedigree, women are represented by circles and males by squares. Each row of a pedigree represents one generation of the family. A medical pedigree doesn't only contain the disease status (whether a person in the family had a certain disease or not), but it also includes other relevant information such as ethnicity and age at disease onset, which might also influence the risk of disease.

Having a comprehensive family health history can be essential in identifying those family members who have an increased risk of developing certain diseases, such as cancer and cardiovascular disease. This helps in creating personalized disease prevention strategies based on that individual's specific risk factors.

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