Question

A chromosomal translocation from chromosome 22 to chromosome 9, also called the Philadelphia chromosome, is associated with a specific type of

O leukemia.
O colon cancer.
O breast cancer.
O lung cancer.

Answer 1

The Philadelphia chromosome is associated with chronic myeloid leukemia, a specific type of leukemia.

Step-by-step explanation:

A chromosomal translocation refers to an abnormal rearrangement of genetic material between two non-homologous chromosomes. In the case of the Philadelphia chromosome, it is a specific type of chromosomal translocation where a piece of chromosome 22 is exchanged with a piece of chromosome 9.

The Philadelphia chromosome is associated with a specific type of leukemia known as chronic myeloid leukemia (CML). This translocation results in the fusion of the BCR (breakpoint cluster region) gene on chromosome 22 with the ABL1 (Abelson tyrosine-protein kinase 1) gene on chromosome 9, leading to the production of an abnormal protein that promotes the uncontrolled growth of white blood cells.

This genetic abnormality is not directly associated with colon cancer, breast cancer, or lung cancer. It is specifically linked to the development of chronic myeloid leukemia.

Learn more about Chromosomal translocation and its association with chronic myeloid leukemia