Final answer:
The area of a square picture with 16-inch sides is 256 square inches.
Step-by-step explanation:
The area of a square can be found by multiplying the length of one side by itself. In this case, the side length is 16 inches. So, the area of the square picture would be 16 x 16 = 256 square inches.
Learn more about Calculating the area of a square