Final answer:
The Southeast region was one of the earliest settled regions of North America by Native American tribes and European explorers.
Step-by-step explanation:
The Southeast region was one of the earliest settled regions of North America. The Native American tribes, such as the Cherokee, Choctaw, and Creek, inhabited this area for thousands of years before European explorers arrived. These explorers, including the Spanish and the French, established colonies and settlements in the Southeast, bringing their culture and influencing the region's history.
Learn more about Settlement of the Southeast region