Final answer:
The arrival of Europeans in the Americas in the 1400s greatly impacted the ways of life of Native Americans.
Step-by-step explanation:
The event that would forever change the ways of life of Native Americans in the 1400s was when Europeans arrived in the Americas. This event brought significant changes to Native American cultures as they encountered foreign diseases, underwent forced labor and slavery, and were displaced from their lands. It also marked the beginning of a long period of colonization and exploitation of their resources by the European powers.
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