Final answer:
The first symptoms to manifest in early HIV/AIDS patients were rare infections that indicated a weakened immune system.
Step-by-step explanation:
Among the first symptoms to manifest in early HIV/AIDS patients were rare infections. These infections occurred due to the weakening of the immune system caused by the virus. Some examples of these rare infections include Pneumocystis pneumonia, Kaposi's sarcoma, and Toxoplasmosis. These symptoms were significant because they indicated a compromised immune system and were often a sign of HIV/AIDS.
Learn more about early symptoms of HIV/AIDS